#include <Hepatic.h>

Inheritance diagram for biogears::Hepatic:

[legend]

Public Member Functions
virtual	~Hepatic () override

const char *	classname () const override

size_t	hash_code () const override

void	Clear () override

void	Initialize () override
	Initializes system properties to valid homeostatic values. More...

virtual bool	Load (const CDM::BioGearsHepaticSystemData &in)

virtual CDM::BioGearsHepaticSystemData *	Unload () const override

SEScalar &	CalculateLiverSOFA ()

void	AtSteadyState () override
	Determines if the engine is stable. More...

void	PreProcess () override
	Preprocess function. More...

void	Process () override
	Process function. More...

void	PostProcess () override
	PostProcess function. More...

Public Member Functions inherited from biogears::SEHepaticSystem
	SEHepaticSystem (Logger *logger)

	~SEHepaticSystem () override

const SEScalar *	GetScalar (const char *name) override

const SEScalar *	GetScalar (const std::string &name) override

bool	Load (const CDM::HepaticSystemData &in)

Tree< const char * >	GetPhysiologyRequestGraph () const override

bool	HasKetoneProductionRate () const

SEScalarAmountPerTime &	GetKetoneProductionRate ()

double	GetKetoneProductionRate (const AmountPerTimeUnit &unit) const

bool	HasHepaticGluconeogenesisRate () const

SEScalarMassPerTime &	GetHepaticGluconeogenesisRate ()

double	GetHepaticGluconeogenesisRate (const MassPerTimeUnit &unit) const

Public Member Functions inherited from biogears::SESystem
	SESystem (Logger *logger)

virtual	~SESystem ()

bool	Load (const CDM::SystemData &in)

Public Member Functions inherited from biogears::Loggable
	Loggable ()

	Loggable (Logger *log)

virtual	~Loggable ()

virtual Logger *	GetLogger () const

Static Public Member Functions
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()

static double	CalculateRelativeHormoneChange (double insulinSetPoint_pmol_Per_L, double glucagonSetPoint_pg_Per_mL, SELiquidSubstanceQuantity currentInsulin, SELiquidSubstanceQuantity currentGlucagon, BioGears &m_data)
	Calculates the relative change in insulin to glucagon to determine direction of nutrient flow. More...

Static Public Member Functions inherited from biogears::SEHepaticSystem
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()

Static Public Member Functions inherited from biogears::SESystem
static const SEScalar *	GetScalar (const char name, std::vector< SESystem > *systems)

static const SEScalar *	GetScalar (const std::string &name, std::vector< SESystem * > *systems)

Protected Member Functions
	Hepatic (BioGears &bg)

virtual void	Unload (CDM::BioGearsHepaticSystemData &data) const

void	SetUp () override
	Initializes parameters for the Hepatic Class. More...

void	ProduceAlbumin (double duration_s)
	Flat Rate production of albumin in the liver. More...

void	Glycogenesis ()
	Removes excess glucose from blood to store as glycogen. More...

void	Glycogenolysis ()
	Removes glucose from storage as glycogen and puts into blood. More...

void	Lipogenesis ()
	Generation of new TAG from AA and glucose in times of excess. More...

void	Gluconeogenesis ()
	The liver's process of generating new glucose from lactate, AA, and TAG. More...

Protected Member Functions inherited from biogears::SEHepaticSystem
void	Unload (CDM::HepaticSystemData &data) const

Protected Member Functions inherited from biogears::SESystem
void	Unload (CDM::SystemData &data) const

Protected Member Functions inherited from biogears::Loggable
virtual void	Debug (const char msg, const char origin="") const

virtual void	Debug (const std::string &msg, const std::string &origin=empty) const

virtual void	Debug (std::ostream &msg, const std::string &origin=empty) const

virtual void	Info (const char msg, const char origin="") const

virtual void	Info (const std::string &msg, const std::string &origin=empty) const

virtual void	Info (std::ostream &msg, const std::string &origin=empty) const

virtual void	Warning (const char msg, const char origin="") const

virtual void	Warning (const std::string &msg, const std::string &origin=empty) const

virtual void	Warning (std::ostream &msg, const std::string &origin=empty) const

virtual void	Error (const char msg, const char origin="") const

virtual void	Error (const std::string msg, const std::string origin=empty) const

virtual void	Error (std::ostream &msg, const std::string &origin=empty) const

virtual void	Fatal (const char msg, const char origin="") const

virtual void	Fatal (const std::string &msg, const std::string &origin=empty) const

virtual void	Fatal (std::ostream &msg, const std::string &origin=empty) const

Protected Member Functions inherited from biogears::BioGearsSystem
virtual void	LoadState ()

Static Protected Member Functions
static auto	make_unique (BioGears &bg) -> std::unique_ptr< Hepatic >

Protected Attributes
BioGears &	m_data

std::stringstream	m_ss

double	m_dt_s

double	m_maxLiverGlycogen_g

double	m_maxMuscleGlycogen_g

double	m_AlbuminProdutionRate_g_Per_s

SELiquidSubstanceQuantity *	m_liverInsulin = nullptr

SELiquidSubstanceQuantity *	m_liverGlucagon = nullptr

SELiquidSubstanceQuantity *	m_liverVascularGlucose = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularGlucose = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularAA = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularTAG = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularUrea = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularLactate = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularO2 = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularCO2 = nullptr

SELiquidSubstanceQuantity *	m_liverExtracellularKetones = nullptr

SELiquidSubstanceQuantity *	m_muscleInsulin = nullptr

SELiquidSubstanceQuantity *	m_muscleGlucagon = nullptr

SELiquidSubstanceQuantity *	m_muscleVascularGlucose = nullptr

SELiquidSubstanceQuantity *	m_LiverTissueAlbumin = nullptr

SESubstance *	m_Glucagon

SESubstance *	m_Insulin

SESubstance *	m_Glucose

SESubstance *	m_AminoAcids

SESubstance *	m_Triacylglycerol

SESubstance *	m_Urea

SESubstance *	m_Lactate

SESubstance *	m_O2

SESubstance *	m_CO2

SESubstance *	m_Ketones

SESubstance *	m_Albumin

SETissueSystem *	m_tsu

SEEnergySystem *	m_energy

SEPatient *	m_Patient

Protected Attributes inherited from biogears::SEHepaticSystem
SEScalarAmountPerTime *	m_KetoneProductionRate

SEScalarMassPerTime *	m_HepaticGluconeogenesisRate

Protected Attributes inherited from biogears::SESystem
std::stringstream	m_ss

Protected Attributes inherited from biogears::Loggable
Logger *	m_Logger

Friends
class	BioGears

class	BioGearsEngineTest

Additional Inherited Members
Static Public Attributes inherited from biogears::Loggable
static const std::string	empty

static const char *	empty_cStr

Detailed Description

Constructor & Destructor Documentation

biogears::Hepatic::Hepatic ( BioGears & bg )

protected

biogears::Hepatic::~Hepatic ( )

overridevirtual

Member Function Documentation

void biogears::Hepatic::AtSteadyState ( )

overridevirtual

Determines if the engine is stable.

When the engine is stable, the CDM makes this call to update the member variable.

Reimplemented from biogears::BioGearsSystem.

SEScalar & biogears::Hepatic::CalculateLiverSOFA ( )

double biogears::Hepatic::CalculateRelativeHormoneChange	(	double	insulinSetPoint_pmol_Per_L,
		double	glucagonSetPoint_pg_Per_mL,
		SELiquidSubstanceQuantity *	currentInsulin,
		SELiquidSubstanceQuantity *	currentGlucagon,
		BioGears &	m_data
	)

static

Calculates the relative change in insulin to glucagon to determine direction of nutrient flow.

Calculate a percent deviation from given insulin and glucagon set points, then return the relative deviation in insulin. So, if a positive number is returned, insulin increased more than glucagon did, and vice versa. A zero value means insulin and glucagon didn't change or stayed the same relative to each other.

const char* biogears::Hepatic::classname ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEHepaticSystem.

void biogears::Hepatic::Clear ( )

overridevirtual

Reimplemented from biogears::SEHepaticSystem.

void biogears::Hepatic::Gluconeogenesis ( )

protected

The liver's process of generating new glucose from lactate, AA, and TAG.

During times of low insulin vs. glucagon, the liver recombines lactate into glucose, deaminates and combines AA to make glucose, and splits TAG to make the glycogen backbone into glucose. Fat breakdown results in ketones. These are energy and O2 consuming processes.

void biogears::Hepatic::Glycogenesis ( )

protected

Removes excess glucose from blood to store as glycogen.

Uses relative changes in insulin and glucagon to determine if new glycogen should be generated from blood glucose. There is no glycogen substance, so store off glucose in a Hepatic member variable.

void biogears::Hepatic::Glycogenolysis ( )

protected

Removes glucose from storage as glycogen and puts into blood.

Uses relative changes in insulin and glucagon to determine if glycogen should be broken down to glucose and moved to bloodstream.

size_t biogears::Hepatic::hash_code ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEHepaticSystem.

void biogears::Hepatic::Initialize ( )

overridevirtual

Initializes system properties to valid homeostatic values.

[90]

[30]

Reimplemented from biogears::BioGearsSystem.

void biogears::Hepatic::Lipogenesis ( )

protected

Generation of new TAG from AA and glucose in times of excess.

Triacylglycerol is generated from excess glucose or amino acids. The amounts of each substance that are converted to TAG depend on the relative concentrations of those substances in the liver. Lipogenesis is an ATP-consuming process, but we assume that energy consumption is rolled into BMR.

bool biogears::Hepatic::Load ( const CDM::BioGearsHepaticSystemData & in )

virtual

auto biogears::Hepatic::make_unique ( BioGears & bg ) -> std::unique_ptr<Hepatic>

staticprotected

void biogears::Hepatic::PostProcess ( )

overridevirtual

PostProcess function.

Implements biogears::BioGearsSystem.

void biogears::Hepatic::PreProcess ( )

overridevirtual

Preprocess function.

Implements biogears::BioGearsSystem.

void biogears::Hepatic::Process ( )

overridevirtual

Process function.

Implements biogears::BioGearsSystem.

void biogears::Hepatic::ProduceAlbumin ( double duration_s )

protected

Flat Rate production of albumin in the liver.

Parameters

duration_s Time period for production of albumin in seconds.

The mass of albumin to produce is calculated from a flat rate production value and the time passed. This mass is added to the liver. The rate is currently specified as .15 mg/s as found in [153]

void biogears::Hepatic::SetUp ( )

overrideprotectedvirtual

Initializes parameters for the Hepatic Class.

Initializes member variables and system level values on the common data model.

[153]

Implements biogears::BioGearsSystem.

static size_t biogears::Hepatic::TypeHash ( )

inlinestatic

static constexpr char const* const biogears::Hepatic::TypeTag ( )

inlinestatic

CDM::BioGearsHepaticSystemData * biogears::Hepatic::Unload ( ) const

overridevirtual

Reimplemented from biogears::SEHepaticSystem.

void biogears::Hepatic::Unload ( CDM::BioGearsHepaticSystemData & data ) const

protectedvirtual

Friends And Related Function Documentation

friend class BioGears

friend

friend class BioGearsEngineTest

friend

Member Data Documentation

SESubstance* biogears::Hepatic::m_Albumin

protected

double biogears::Hepatic::m_AlbuminProdutionRate_g_Per_s

protected

SESubstance* biogears::Hepatic::m_AminoAcids

protected

SESubstance* biogears::Hepatic::m_CO2

protected

BioGears& biogears::Hepatic::m_data

protected

double biogears::Hepatic::m_dt_s

protected

SEEnergySystem* biogears::Hepatic::m_energy

protected

SESubstance* biogears::Hepatic::m_Glucagon

protected

SESubstance* biogears::Hepatic::m_Glucose

protected

SESubstance* biogears::Hepatic::m_Insulin

protected

SESubstance* biogears::Hepatic::m_Ketones

protected

SESubstance* biogears::Hepatic::m_Lactate

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularAA = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularCO2 = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularGlucose = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularKetones = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularLactate = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularO2 = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularTAG = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverExtracellularUrea = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverGlucagon = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverInsulin = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_LiverTissueAlbumin = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_liverVascularGlucose = nullptr

protected

double biogears::Hepatic::m_maxLiverGlycogen_g

protected

double biogears::Hepatic::m_maxMuscleGlycogen_g

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_muscleGlucagon = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_muscleInsulin = nullptr

protected

SELiquidSubstanceQuantity* biogears::Hepatic::m_muscleVascularGlucose = nullptr

protected

SESubstance* biogears::Hepatic::m_O2

protected

SEPatient* biogears::Hepatic::m_Patient

protected

std::stringstream biogears::Hepatic::m_ss

protected

SESubstance* biogears::Hepatic::m_Triacylglycerol

protected

SETissueSystem* biogears::Hepatic::m_tsu

protected

SESubstance* biogears::Hepatic::m_Urea

protected

Public Member Functions

Static Public Member Functions

Protected Member Functions

Static Protected Member Functions

Protected Attributes

Friends

Additional Inherited Members

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Friends And Related Function Documentation

Member Data Documentation