#include <Endocrine.h>

Inheritance diagram for biogears::Endocrine:

[legend]

Public Member Functions
virtual	~Endocrine () override

const char *	classname () const override

size_t	hash_code () const override

void	Clear () override

void	Initialize () override
	Initializes system properties to valid homeostatic values. More...

virtual bool	Load (const CDM::BioGearsEndocrineSystemData &in)

virtual CDM::BioGearsEndocrineSystemData *	Unload () const override

void	AtSteadyState () override
	Notify systems that steady state has been achieved. More...

void	PreProcess () override
	Endocrine Preprocess function. More...

void	Process () override
	Endocrine process function. More...

void	PostProcess () override
	Endocrine PostProcess function. More...

Public Member Functions inherited from biogears::SEEndocrineSystem
	SEEndocrineSystem (Logger *logger)

	~SEEndocrineSystem () override

const SEScalar *	GetScalar (const char *name) override

const SEScalar *	GetScalar (const std::string &name) override

bool	Load (const CDM::EndocrineSystemData &in)

Tree< const char * >	GetPhysiologyRequestGraph () const override

bool	HasInsulinSynthesisRate () const

SEScalarAmountPerTime &	GetInsulinSynthesisRate ()

double	GetInsulinSynthesisRate (const AmountPerTimeUnit &unit) const

bool	HasGlucagonSynthesisRate () const

SEScalarAmountPerTime &	GetGlucagonSynthesisRate ()

double	GetGlucagonSynthesisRate (const AmountPerTimeUnit &unit) const

Public Member Functions inherited from biogears::SESystem
	SESystem (Logger *logger)

virtual	~SESystem ()

bool	Load (const CDM::SystemData &in)

Public Member Functions inherited from biogears::Loggable
	Loggable ()

	Loggable (Logger *log)

virtual	~Loggable ()

virtual Logger *	GetLogger () const

Static Public Member Functions
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()

Static Public Member Functions inherited from biogears::SEEndocrineSystem
static size_t	TypeHash ()

static constexpr char const *const	TypeTag ()

Static Public Member Functions inherited from biogears::SESystem
static const SEScalar *	GetScalar (const char name, std::vector< SESystem > *systems)

static const SEScalar *	GetScalar (const std::string &name, std::vector< SESystem * > *systems)

Protected Member Functions
	Endocrine (BioGears &bg)

virtual void	Unload (CDM::BioGearsEndocrineSystemData &data) const

void	SetUp () override

void	ProcessOverride ()
	determine override requirements from user defined inputs More...

void	OverrideControlLoop ()

Protected Member Functions inherited from biogears::SEEndocrineSystem
void	Unload (CDM::EndocrineSystemData &data) const

Protected Member Functions inherited from biogears::SESystem
void	Unload (CDM::SystemData &data) const

Protected Member Functions inherited from biogears::Loggable
virtual void	Debug (const char msg, const char origin="") const

virtual void	Debug (const std::string &msg, const std::string &origin=empty) const

virtual void	Debug (std::ostream &msg, const std::string &origin=empty) const

virtual void	Info (const char msg, const char origin="") const

virtual void	Info (const std::string &msg, const std::string &origin=empty) const

virtual void	Info (std::ostream &msg, const std::string &origin=empty) const

virtual void	Warning (const char msg, const char origin="") const

virtual void	Warning (const std::string &msg, const std::string &origin=empty) const

virtual void	Warning (std::ostream &msg, const std::string &origin=empty) const

virtual void	Error (const char msg, const char origin="") const

virtual void	Error (const std::string msg, const std::string origin=empty) const

virtual void	Error (std::ostream &msg, const std::string &origin=empty) const

virtual void	Fatal (const char msg, const char origin="") const

virtual void	Fatal (const std::string &msg, const std::string &origin=empty) const

virtual void	Fatal (std::ostream &msg, const std::string &origin=empty) const

Protected Member Functions inherited from biogears::BioGearsSystem
virtual void	LoadState ()

Static Protected Member Functions
static auto	make_unique (BioGears &bg) -> std::unique_ptr< Endocrine >

Protected Attributes
BioGears &	m_data

Protected Attributes inherited from biogears::SEEndocrineSystem
SEScalarAmountPerTime *	m_InsulinSynthesisRate

SEScalarAmountPerTime *	m_GlucagonSynthesisRate

Protected Attributes inherited from biogears::SESystem
std::stringstream	m_ss

Protected Attributes inherited from biogears::Loggable
Logger *	m_Logger

Private Member Functions
void	SynthesizeInsulin ()
	Calculate the rate of insulin production. More...

void	SynthesizeGlucagon ()
	Calculate the rate of glucagon production. More...

void	ReleaseEpinephrine ()
	Release epinephrine into the bloodstream and handle sympathetic responses. More...

Private Attributes
double	m_dt_s

double	m_InsulinMolarMass_g_Per_mol

double	m_AverageBiologicalDebt

double	m_GlucagonMolarMass_g_Per_mol

SELiquidSubstanceQuantity *	m_AortaGlucose = nullptr

SELiquidSubstanceQuantity *	m_AortaEpinephrine = nullptr

SELiquidSubstanceQuantity *	m_rKidneyEpinephrine = nullptr

SELiquidSubstanceQuantity *	m_lKidneyEpinephrine = nullptr

SELiquidSubstanceQuantity *	m_SplanchnicInsulin = nullptr

SELiquidSubstanceQuantity *	m_SplanchnicGlucagon = nullptr

Friends
class	BioGears

class	BioGearsEngineTest

Additional Inherited Members
Static Public Attributes inherited from biogears::Loggable
static const std::string	empty

static const char *	empty_cStr

Detailed Description

The BioGears� endocrine system is a rudimentary system with only one stimulus (increased carbon dioxide partial pressure in the blood stream) and two hormones (epinephrine and norepinephrine). The release of the hormones in response to the stimuli to represent the response of the sympathetic nervous system. In the future, additional stimuli and additional hormones will be added.

Constructor & Destructor Documentation

biogears::Endocrine::Endocrine ( BioGears & bg )

protected

biogears::Endocrine::~Endocrine ( )

overridevirtual

Member Function Documentation

void biogears::Endocrine::AtSteadyState ( )

overridevirtual

Notify systems that steady state has been achieved.

Reimplemented from biogears::BioGearsSystem.

const char* biogears::Endocrine::classname ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEEndocrineSystem.

void biogears::Endocrine::Clear ( )

overridevirtual

Reimplemented from biogears::SEEndocrineSystem.

size_t biogears::Endocrine::hash_code ( ) const

inlineoverridevirtual

Reimplemented from biogears::SEEndocrineSystem.

void biogears::Endocrine::Initialize ( )

overridevirtual

Initializes system properties to valid homeostatic values.

Reimplemented from biogears::BioGearsSystem.

bool biogears::Endocrine::Load ( const CDM::BioGearsEndocrineSystemData & in )

virtual

auto biogears::Endocrine::make_unique ( BioGears & bg ) -> std::unique_ptr<Endocrine>

staticprotected

void biogears::Endocrine::OverrideControlLoop ( )

protected

void biogears::Endocrine::PostProcess ( )

overridevirtual

Endocrine PostProcess function.

The Endocrine system does not currently have any PostProcess functionality.

Implements biogears::BioGearsSystem.

void biogears::Endocrine::PreProcess ( )

overridevirtual

Endocrine Preprocess function.

Currently, only three hormones exist in the BioGears system: epinephrine, insulin, and glucagon. These functions determine the release of these hormones. The hormones will then circulate using the transport and substances methodologies.

Implements biogears::BioGearsSystem.

void biogears::Endocrine::Process ( )

overridevirtual

Endocrine process function.

The Endocrine system does not currently have any Process functionality.

Implements biogears::BioGearsSystem.

void biogears::Endocrine::ProcessOverride ( )

protected

determine override requirements from user defined inputs

User specified override outputs that are specific to the cardiovascular system are implemented here. If overrides aren't present for this system then this function will not be called during preprocess.

void biogears::Endocrine::ReleaseEpinephrine ( )

private

Release epinephrine into the bloodstream and handle sympathetic responses.

Epinephrine is released at a basal rate of .18 ug/min [22] from the kidneys. During certain events, the release rate of epinephrine increases. This is sympathetic response.

void biogears::Endocrine::SetUp ( )

overrideprotectedvirtual

Implements biogears::BioGearsSystem.

void biogears::Endocrine::SynthesizeGlucagon ( )

private

Calculate the rate of glucagon production.

The glucagon production rate is set based on the aorta glucose concentration to values that allow it to have stable concentrations when paired with the clearance rate of 9 mL/min kg from https://www.ncbi.nlm.nih.gov/pubmed/773949

void biogears::Endocrine::SynthesizeInsulin ( )

private

Calculate the rate of insulin production.

The insulin production rate is calculated based on the relevant range of glucose and instantaneous concentration of glucose in the aorta (representative of the body). The equation for insulin production is from [tolic2000insulin] Patients with diabetes mellitus may have a reduced capacity for insulin production or insulin resistance, based on severity.

static size_t biogears::Endocrine::TypeHash ( )

inlinestatic

static constexpr char const* const biogears::Endocrine::TypeTag ( )

inlinestatic

CDM::BioGearsEndocrineSystemData * biogears::Endocrine::Unload ( ) const

overridevirtual

Reimplemented from biogears::SEEndocrineSystem.

void biogears::Endocrine::Unload ( CDM::BioGearsEndocrineSystemData & data ) const

protectedvirtual

Friends And Related Function Documentation

friend class BioGears

friend

friend class BioGearsEngineTest

friend

Member Data Documentation

SELiquidSubstanceQuantity* biogears::Endocrine::m_AortaEpinephrine = nullptr

private

SELiquidSubstanceQuantity* biogears::Endocrine::m_AortaGlucose = nullptr

private

double biogears::Endocrine::m_AverageBiologicalDebt

private

BioGears& biogears::Endocrine::m_data

protected

double biogears::Endocrine::m_dt_s

private

double biogears::Endocrine::m_GlucagonMolarMass_g_Per_mol

private

double biogears::Endocrine::m_InsulinMolarMass_g_Per_mol

private

SELiquidSubstanceQuantity* biogears::Endocrine::m_lKidneyEpinephrine = nullptr

private

SELiquidSubstanceQuantity* biogears::Endocrine::m_rKidneyEpinephrine = nullptr

private

SELiquidSubstanceQuantity* biogears::Endocrine::m_SplanchnicGlucagon = nullptr

private

SELiquidSubstanceQuantity* biogears::Endocrine::m_SplanchnicInsulin = nullptr

private

Public Member Functions

Static Public Member Functions

Protected Member Functions

Static Protected Member Functions

Protected Attributes

Private Member Functions

Private Attributes

Friends

Additional Inherited Members

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Friends And Related Function Documentation

Member Data Documentation