The SaturationCalculator class holds the blood gas distribution model. More...

#include <Saturation.h>

Inheritance diagram for biogears::SaturationCalculator:

Public Member Functions
virtual	~SaturationCalculator ()

void	Initialize (SESubstanceManager &substances)

void	SetBodyState (const SEScalarMassPerVolume &AlbuminConcentration, const SEScalarFraction &Hematocrit, const SEScalarTemperature &Temperature, const SEScalarAmountPerVolume &StrongIonDifference, const SEScalarAmountPerVolume &Phosphate)

void	CalculateBloodGasDistribution (SELiquidCompartment &cmpt)
	Determines species distribution of oxygen and carbon dioxide in a vascular compartment. More...

void	CalculateCarbonMonoxideSpeciesDistribution (SELiquidCompartment &cmpt)
	Determines the carbon monoxide (CO) species distribution in a compartment and sets the CO saturation. More...

Public Member Functions inherited from biogears::Loggable
	Loggable ()

	Loggable (Logger *log)

virtual	~Loggable ()

virtual Logger *	GetLogger () const

Protected Member Functions
	SaturationCalculator (BioGears &bg)

void	CalculateHemoglobinSaturations (double O2PartialPressureGuess_mmHg, double CO2PartialPressureGuess_mmHg, double pH, double temperature_C, double hematocrit, double &OxygenSaturation, double &CarbonDioxideSaturation, double CO2_scaling_factor)
	Computes the percent saturation of hemoglobin by oxygen and carbon dioxide. More...

bool	DistributeHemoglobinBySaturation ()
	Distributes hemoglobin species for a given pair of oxygen and carbon dioxide saturation fractions. More...

Protected Member Functions inherited from biogears::Loggable
virtual void	Debug (const char msg, const char origin="") const

virtual void	Debug (const std::string &msg, const std::string &origin=empty) const

virtual void	Debug (std::ostream &msg, const std::string &origin=empty) const

virtual void	Info (const char msg, const char origin="") const

virtual void	Info (const std::string &msg, const std::string &origin=empty) const

virtual void	Info (std::ostream &msg, const std::string &origin=empty) const

virtual void	Warning (const char msg, const char origin="") const

virtual void	Warning (const std::string &msg, const std::string &origin=empty) const

virtual void	Warning (std::ostream &msg, const std::string &origin=empty) const

virtual void	Error (const char msg, const char origin="") const

virtual void	Error (const std::string msg, const std::string origin=empty) const

virtual void	Error (std::ostream &msg, const std::string &origin=empty) const

virtual void	Fatal (const char msg, const char origin="") const

virtual void	Fatal (const std::string &msg, const std::string &origin=empty) const

virtual void	Fatal (std::ostream &msg, const std::string &origin=empty) const

Static Protected Member Functions
static auto	make_unique (BioGears &bg) -> std::unique_ptr< SaturationCalculator >

Protected Attributes
BioGears &	m_data

SESubstance *	m_O2

SESubstance *	m_Hb

SESubstance *	m_HbO2

SESubstance *	m_HbO2CO2

SESubstance *	m_CO2

SESubstance *	m_CO

SESubstance *	m_HbCO

SESubstance *	m_HCO3

SESubstance *	m_HbCO2

double	m_O2_g_Per_mol

double	m_CO2_g_Per_mol

double	m_HCO3_g_Per_mol

double	m_Hb_g_Per_mol

double	m_HbO2_g_Per_mol

double	m_HbCO2_g_Per_mol

double	m_HbO2CO2_g_Per_mol

SELiquidCompartment *	m_cmpt

SELiquidSubstanceQuantity *	m_subO2Q

SELiquidSubstanceQuantity *	m_subCO2Q

SELiquidSubstanceQuantity *	m_subCOQ

SELiquidSubstanceQuantity *	m_subHbCOQ

SELiquidSubstanceQuantity *	m_subHCO3Q

SELiquidSubstanceQuantity *	m_subHbQ

SELiquidSubstanceQuantity *	m_subHbO2Q

SELiquidSubstanceQuantity *	m_subHbCO2Q

SELiquidSubstanceQuantity *	m_subHbO2CO2Q

double	m_albumin_g_per_L

double	m_hematocrit

double	m_temperature_C

double	m_StrongIonDifference_mmol_Per_L

double	m_Phosphate_mmol_Per_L

Protected Attributes inherited from biogears::Loggable
Logger *	m_Logger

Friends
struct	error_functor

class	BioGears

class	BioGearsEngineTest

Additional Inherited Members
Static Public Attributes inherited from biogears::Loggable
static const std::string	empty

static const char *	empty_cStr

Detailed Description

The SaturationCalculator class holds the blood gas distribution model.

Constructor & Destructor Documentation

biogears::SaturationCalculator::SaturationCalculator ( BioGears & bg )

protected

biogears::SaturationCalculator::~SaturationCalculator ( )

virtual

Member Function Documentation

void biogears::SaturationCalculator::CalculateBloodGasDistribution ( SELiquidCompartment & cmpt )

Determines species distribution of oxygen and carbon dioxide in a vascular compartment.

This method computes the distribution of dissolved and hemoglobin-bound oxygen and carbon dioxide in the blood and also the fraction of total carbon dioxide that is in bicarbonate form. The method uses the Eigen HybridNonLinearSolver to solve the system of equations described in bloodchemistry-approach.

void biogears::SaturationCalculator::CalculateCarbonMonoxideSpeciesDistribution ( SELiquidCompartment & cmpt )

Determines the carbon monoxide (CO) species distribution in a compartment and sets the CO saturation.

This method computes the fraction of hemoglobin that is bound with carbon monoxide (CO). Conservation of mass and the Haldane relationship described in [39] are used to compute the distribution of carbon monoxide species in a compartment. The hemoglobin available for oxygen binding is then decremented with the assumption that CO binds first to deoxyhemoglobin, then to oxyhemoglobin, then to oxycarbaminohemoglobin, and finally to carbaminohemoglobin. In binding to the relative hemoglobin species, CO converts the species to carboxyhemoglobin. Currently, the small mass of gas bound to the non-deoxy species is lost. This is a known limitation that does not affect the resultant steady-state gas distribution.

void biogears::SaturationCalculator::CalculateHemoglobinSaturations	(	double	O2PartialPressureGuess_mmHg,
		double	CO2PartialPressureGuess_mmHg,
		double	pH,
		double	temperature_C,
		double	hematocrit,
		double &	OxygenSaturation,
		double &	CarbonDioxideSaturation,
		double	CO2_scaling_factor
	)

protected

Computes the percent saturation of hemoglobin by oxygen and carbon dioxide.

This code is adapted directly from the model described in [58].

bool biogears::SaturationCalculator::DistributeHemoglobinBySaturation ( )

protected

Distributes hemoglobin species for a given pair of oxygen and carbon dioxide saturation fractions.

Because oxycarbaminohemoglobin includes both oxygen and carbon dioxide, the species distribution of hemoglobins at a given fraction of O2 and CO2 saturation is an under-constrained problem. The method first attempts an assumed solution. If the assumed solution requires more hemoglobin than is available, the method steps towards a solution that minimizes total hemoglobin use.

void biogears::SaturationCalculator::Initialize ( SESubstanceManager & substances )

auto biogears::SaturationCalculator::make_unique ( BioGears & bg ) -> std::unique_ptr<SaturationCalculator>

staticprotected

void biogears::SaturationCalculator::SetBodyState	(	const SEScalarMassPerVolume &	AlbuminConcentration,
		const SEScalarFraction &	Hematocrit,
		const SEScalarTemperature &	Temperature,
		const SEScalarAmountPerVolume &	StrongIonDifference,
		const SEScalarAmountPerVolume &	Phosphate
	)

Friends And Related Function Documentation

friend class BioGears

friend

friend class BioGearsEngineTest

friend

friend struct error_functor

friend

Member Data Documentation

double biogears::SaturationCalculator::m_albumin_g_per_L

protected

SELiquidCompartment* biogears::SaturationCalculator::m_cmpt

protected

SESubstance* biogears::SaturationCalculator::m_CO

protected

SESubstance* biogears::SaturationCalculator::m_CO2

protected

double biogears::SaturationCalculator::m_CO2_g_Per_mol

protected

BioGears& biogears::SaturationCalculator::m_data

protected

SESubstance* biogears::SaturationCalculator::m_Hb

protected

double biogears::SaturationCalculator::m_Hb_g_Per_mol

protected

SESubstance* biogears::SaturationCalculator::m_HbCO

protected

SESubstance* biogears::SaturationCalculator::m_HbCO2

protected

double biogears::SaturationCalculator::m_HbCO2_g_Per_mol

protected

SESubstance* biogears::SaturationCalculator::m_HbO2

protected

double biogears::SaturationCalculator::m_HbO2_g_Per_mol

protected

SESubstance* biogears::SaturationCalculator::m_HbO2CO2

protected

double biogears::SaturationCalculator::m_HbO2CO2_g_Per_mol

protected

SESubstance* biogears::SaturationCalculator::m_HCO3

protected

double biogears::SaturationCalculator::m_HCO3_g_Per_mol

protected

double biogears::SaturationCalculator::m_hematocrit

protected

SESubstance* biogears::SaturationCalculator::m_O2

protected

double biogears::SaturationCalculator::m_O2_g_Per_mol

protected

double biogears::SaturationCalculator::m_Phosphate_mmol_Per_L

protected

double biogears::SaturationCalculator::m_StrongIonDifference_mmol_Per_L

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subCO2Q

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subCOQ

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHbCO2Q

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHbCOQ

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHbO2CO2Q

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHbO2Q

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHbQ

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subHCO3Q

protected

SELiquidSubstanceQuantity* biogears::SaturationCalculator::m_subO2Q

protected

double biogears::SaturationCalculator::m_temperature_C

protected

Public Member Functions

Protected Member Functions

Static Protected Member Functions

Protected Attributes

Friends

Additional Inherited Members

Detailed Description

Constructor & Destructor Documentation

Member Function Documentation

Friends And Related Function Documentation

Member Data Documentation