The CBDST conference will include technical discussions on innovations in CB defense.
The BioGears team is excited to participate in the conference and will present a poster: "BioGears: Simulating Whole-Body Response to Chemical Exposure."
BioGears provides critical in-silico models that integrate CB exposure and PD/PK effects to simulate individual or population-level response to agent release events. Using the BioGears framework to integrate previously disparate models into a single system that enables end-to-end multi-scale modeling would have wide-reaching consequences for the decision support community.
The BioGears team recently attended the Virtual Physiological Human Conference. We submitted and presented a paper titled, “ A Framework for Multiscale Physiology: Towards Individualized Computer Simulation.” The conference also included many topics on state-of-the art research in multiscale modelling of human physiology. We were excited to discuss BioGears research within an international setting and discuss new groups adoption of BioGears!
The Virtual Physiological Human (VPH) is a methodological and technological framework that, once established, will enable collaborative investigation of the human body as a single complex system. The collective framework will make it possible to share resources and observations formed by institutions and organizations creating disparate, but integrated computer models of the mechanical, physical and biochemical functions of a living human body.
In the 22 months since the BioGears® open source human physiology engine was released, there has been an overwhelming response from the research community. BioGears has become an internationally recognized physiology research platform with nearly 3,500 downloads originating from 35+ countries. A recent example is the use of BioGears® for in-silico human modeling; research was conducted by Applied Research Associates, Inc. (ARA), the US Army Institute for Surgical Research (ISR), and the Geneva Foundation.
ARA researchers, Mr. Charlie Fisher (Staff Engineer) and Mr. Chris Argenta (Principal Software Engineer) attended the International Conference on Complex Acute Illness (ICCAI) to present their work. On 13 August 2016, they presented a poster, ‘Forecasting the Trajectory of Blood Loss from Vital Signs Collected at the Bedside,’ that highlighted BioGears’ functionality and research results.
The research team used principle component analysis (machine learning) to develop an autoregressive time series model that predicts physiologic response to a hemorrhage event, specifically looking at mean arterial pressure (MAP). The USAISR provided data for 35 swine models with severe hemorrhages withdrawing ~65% of blood volume prior to intervention. Using this data, ARA’s team was able to scale the test specimen data to the expected human ranges and generated MAP values for a similar event using the hemorrhage model in BioGears. ARA engineers and scientists developed the models using the BioGears Application Programming Interface (API) “as-is”. This work was a proof of concept, and required less than one day to accomplish.
The poster presentation may be downloaded at: http://www.slideshare.net/BioGearsEngine/documents
The BioGears team had a great time at the Medicine Meets Virtual Reality (MMVR) Conference! The team participated in several presentations, and was selected to present 4 posters!
Our PI, Jeff Webb; Lead Physiology Modeler, Rachel Clipp; and Lead Software Developer, Aaron Bray gave a BioGears workshop that included an overview of BioGears and an in-depth tutorial on how to use BioGears. Our slides are posted on our Slide Share page in case you were unable to attend the presentation.
We also want to congratulate our friend and colleague, Cameron Thames, on being a winner in the MMVR poster contest! Great job Cam!
Our latest deployment is intended to be an intermediate release that showcases the expanding capabilities of the BioGears Engine for our user community.
This deployment includes notable updates, such as:
The BioGears team is preparing for the MMVR conference. We will provide a BioGears workshop (7 April, 1:30-5:00pm) that will include presentations and tutorials. Our team is also presenting four posters (7 April, 5:15-7:00pm). We look forward to seeing you there!
The BioGears team is attending the Medicine Meets Virtual Reality (MMVR) Conference and we hope you join us there for the BioGears workshop and poster presentations.
MMVR was conceived in 1991 to explore healthcare’s use of rapidly evolving computing and communications technologies, and 25 years later the curriculum has expanded to encompass a broad range of future-looking healthcare technologies.
On 7 April (Track 3, 1:30-5:00pm) our team will provide a BioGears workshop that will include the following presentations and tutorials:
The goal of the workshop is to provide our user community with the information they need to harness the capabilities of BioGears. Our team is also presenting four posters (7 April, 5:15-7:00pm), immediately following the workshop.
For more information about the learning objectives of the workshop, and our poster presentations, please visit our MMVR Page.
We look forward to seeing you there!